Dış Kaynaklı Proje Süreçleri Yönetim Sistemi
A number of studies regarding the fluorescent materials have been carried out over the past decades aiming to develop novel functionalities for multiple applications, such as imaging of cell organelles, tracing of biological processes, disease diagnosis and treatment, and antibacterial properties. In parallel, numbers of luminescent materials, such as organic dyes, inorganic nanoparticles, metallic nanoparticles, and fluorescent proteins have been developed and utilized as bio-probes. In this regard, organic fluorescent molecules with high photo-stability, low cytotoxicity, high processability, and selectivity towards a particular bio-analyte are of particular interest. Organic fluorophores with advantages, such as high sensitivity, selectivity, biocompatibility, photostability are ideal candidates for a large number of applications in biomedical science, such as, targeting desired cell organelles with low cytotoxicity, drug carriers for infected tissues, selectively killing cancer cells and desired pathogens. All these properties are associated with engineering of fluorophores at the molecular level. In this regard, the proposed project will focus on the synthesis of novel fluorescent probes to cover broad range of biomedical applications, such as sensing, imaging, drug delivery, theranostics, etc. For this purpose, the desired probes will be synthesized by our own developed synthetic protocols and will be further applied/commercialized for the desired biomedical applications, such as in pathogenesis, drug development, clinical diagnosis, and in theranostics. The proposed work will thus provide an approach to acquire novel organic fluorescent materials and commercialize them for desired biomedical applications.